“Attempted murder! Now, honestly, what is that? Do they give a Nobel Prize for attempted chemistry? Do they?” – Sideshow Bob (The Simpsons, S06e05)

about me

Welcome here ! My name is Laurent Vial, and I'm a CNRS research scientist within the Applied Supramolecular Chemistry Group at the Université de Lyon, France. My research interests focus on artificial receptors for biologically relevant molecules with applications as biosensors or therapeutics

my latest publications

• Lost in (Clinical) Translation: Recent Advances in Heparin Neutralization and Monitoring

  B. Ourri, L. Vial^* ACS. Chem. Biol., 2019, 14, DOI:10.1021/acschembio.9b00772

  

• Dendrigraft of Poly-L-lysine as a Promising Candidate for the Reversal of Heparin-based Anticoagulants in Clinical Settings

  B. Ourri, J.-P. Francoia, G. Monard^*, J.-C. Gris^*, J. Leclaire, L. Vial^* ACS. Med. Chem. Lett., 2019, 10, 917

  

  • highlighted by C&EN (link)

  • highlighted by CNRS (link)

  • highlighted by ENS Lyon (link)

    
    

• Wetting the lock and key enthalpically favours polyelectrolytes binding

  E. Jeamet, J. Septavaux, A. Heloin, M. Donnier-Maréchal, M. Dumartin, B. Ourri, P. Mandal, I. Huc, E. Bignon, E. Dumont^*, C. Morell, J.-P. Francoia, F. Perret, L. Vial^* and J. Leclaire^* Chem. Sci., 2019, 10, 277 - open access

  

  • highlighted by CNRS (link)

    
    

• Diastereoselective Synthesis of a Dyn[3]arene with Distinct Binding Behaviors toward Linear Biogenic Polyamines
  

  M. Donnier-Maréchal, J. Septavaux, E. Jeamet, F. Perret, A. Héloin, E. Dumont, J.-C. Rossi, F. Ziarelli, J. Leclaire^* and L. Vial^* Org. Lett. 2018, 20, 2420

• Everything you always wanted to know about poly-L-lysine dendrigrafts (but were afraid to ask)
  

  J.-P. Francoia and L. Vial^* Chem. Eur. J., 2018, 24, 2806

• Digitizing Poly-L-Lysine Dendrigrafts: from Experimental Data to Molecular Dynamics Simulations
  

  J.-P. Francoia, J.-C Rossi, G. Monard^* and L. Vial^* J. Chem. Inf. Model., 2017, 57, 2173

• Chirality Sensing and Discrimination of Lysine Derivatives in Physiological Conditions with a Dyn[4]arene
  

  L. Vial^*, M. Dumartin, M. Donnier-Maréchal, F. Perret, J.-P. Francoia, J. Leclaire^* Chem. Commun., 2016, 52, 14219

• On-demand Cyclophanes: Substituent-directed Self-assembling, Folding and Binding

  P.-T. Skowron, M. Dumartin, E. Jeamet, F. Perret, C. Gourlaouen, A. Baudouin, B. Fenet, J.-V. Naubron, F. Fotiadu, L. Vial and J. Leclaire^* J. Org. Chem., 2016, 81, 654

• ChemBrows: An Open-Source Application Software To Keep Up to Date with the Current Literature

  J.-P. Francoia and L. Vial^* J. Chem. Educ, 2016, 93, 1137 - open access

• A KISS (Keep It Simple, Sensor) Array for Glycosaminoglycans

  J.-P. Francoia and L. Vial^* Chem. Commun., 2015, 51, 17544

• Monitoring Clinical Levels of Heparin in Human Blood Samples with an Indicator-Displacement Assay

  J.-P. Francoia, R. Pascal, and L. Vial^* Chem. Commun., 2015, 51, 1953

• Reduction with tris(2-carboxyethyl)phosphine (TCEP) enables the use of S-sulphonate protecting group for thiol-mediated bioconjugation

  B. Maret, T. Regnier, J.-C. Rossi, L. Garrelly, L. Vial and R. Pascal^* Rsc. Adv., 2014, 4, 7725